MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: pernicious anaemia | 0.642 | 0.216 | 0.00295 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.252 | 0.113 | 0.0258 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | -0.0406 | 0.0216 | 0.06 | Wald ratio | 1 | cis | NA |
| Weight | -0.0337 | 0.0186 | 0.07 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0381 | 0.0211 | 0.0705 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.126 | 0.077 | 0.103 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | -0.062 | 0.0388 | 0.109 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | -0.426 | 0.267 | 0.111 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | -0.0943 | 0.0629 | 0.134 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Cataract | -0.212 | 0.145 | 0.143 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.222 | 0.153 | 0.147 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: asthma | 0.0764 | 0.0549 | 0.164 | Wald ratio | 1 | cis | NA |
| …and 39 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
51 association rows across 26 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| TREM2 protein levels | 3e-113 | rs75932628 | 2 | GCST90470960 | no MR -> candidate analysis |
| Triggering receptor expressed on myeloid cells 2 levels | 2e-96 | rs143332484 | 1 | GCST90249970 | no MR -> candidate analysis |
| Circulating TREML2 levels | 2e-44 | rs62396354 | 1 | GCST90859936 | no MR -> candidate analysis |
| TREML2 protein levels | 3e-42 | rs113582625 | 5 | GCST90470962 | no MR -> candidate analysis |
| Alzheimer’s disease, proxy Alzheimer’s disease or related de | 3e-38 | rs75932628 | 6 | GCST90704646 | no MR -> candidate analysis |
| Alzheimer’s disease | 3e-37 | rs75932628 | 10 | GCST90027158 | no MR -> candidate analysis |
| Alzheimer’s disease or related dementias | 7e-33 | rs75932628 | 2 | GCST90704647 | no MR -> candidate analysis |
| Triggering receptor expressed on myeloid cells 2 level in Ch | 7e-30 | rs73427270 | 1 | GCST90234514 | no MR -> candidate analysis |
| Triggering receptor expressed on myeloid cells 2 (analyte X1 | 1e-25 | rs143332484 | 1 | GCST90422809 | no MR -> candidate analysis |
| Alzheimer’s disease (late onset) | 5e-24 | rs75932628 | 3 | GCST005549 | no MR -> candidate analysis |
| Cerebrospinal fluid soluble TREM2 levels | 7e-19 | rs75932628 | 2 | GCST90454420 | no MR -> candidate analysis |
| Alzheimer’s disease (age of onset) | 8e-17 | rs75932628 | 2 | GCST90093287 | no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
Top diseases by Open Targets association (of 611 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Nasu-Hakola disease | 0.887 | — | established (curated) | no MR -> candidate analysis |
| Alzheimer disease | 0.858 | — | common-variant locus | no MR -> candidate analysis |
| frontotemporal dementia | 0.666 | — | established (curated) | no MR -> candidate analysis |
| hereditary disease | 0.672 | — | established (curated) | no MR -> candidate analysis |
| neurodegenerative disease | 0.551 | — | common-variant locus | no MR -> candidate analysis |
| dementia | 0.546 | — | common-variant locus | no MR -> candidate analysis |
| polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly | 0.559 | — | established (curated) | no MR -> candidate analysis |
| late-onset Alzheimers disease | 0.551 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.159 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.057 | — | common-variant locus | no MR -> candidate analysis |
Of the 10 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Triggering receptor expressed on myeloid cells 2) |
| gnomAD constraint | pLI=7.9e-07, LOEUF=1.27 — LoF-tolerant |
| GWAS Catalog | 70 unique SNPs / 140 rows |
| ClinVar | 202 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 611 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TREM2’ and resolved to ‘Triggering receptor expressed on myeloid cells 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 202 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 51 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9NZC2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000095970/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6196124/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TREM2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TREM2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TREM2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TREM2 — GWAS Catalog search API (live; release not exposed)