MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diastolic blood pressure automated reading | -0.0354 | 0.00993 | 3.67e-04 | Wald ratio | 1 | trans | NA |
| Height | -0.0417 | 0.0123 | 7.24e-04 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.308 | 0.0942 | 0.00109 | Wald ratio | 1 | trans | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0231 | 0.00842 | 0.0061 | Wald ratio | 1 | trans | NA |
| Invasive mucinous ovarian cancer | -0.404 | 0.162 | 0.0128 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: sleep apnoea | 0.322 | 0.13 | 0.0132 | Wald ratio | 1 | trans | NA |
| HOMA-B | -0.0365 | 0.0155 | 0.0183 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: migraine | 0.115 | 0.0503 | 0.0224 | Wald ratio | 1 | trans | NA |
| Weight | -0.0191 | 0.00859 | 0.0258 | Wald ratio | 1 | trans | NA |
| Major depressive disorder | 0.182 | 0.0827 | 0.0278 | Wald ratio | 1 | trans | NA |
| Childhood intelligence | 0.131 | 0.0608 | 0.0312 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | -0.0171 | 0.00798 | 0.0323 | Wald ratio | 1 | trans | NA |
| …and 82 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
25 association rows across 17 traits (23 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Mean corpuscular hemoglobin | 6e-792 | rs5756489 | 3 | GCST90002322 | no MR -> candidate analysis |
| mean corpuscular hemoglobin (MCH, minimum, inv-norm transfor | 1e-323 | rs5756487 | 1 | GCST90479674 | no MR -> candidate analysis |
| mean corpuscular hemoglobin (MCH, maximum, inv-norm transfor | 1e-323 | rs5756487 | 1 | GCST90479672 | no MR -> candidate analysis |
| mean corpuscular hemoglobin (MCH, mean, inv-norm transformed | 1e-323 | rs5756487 | 1 | GCST90479673 | no MR -> candidate analysis |
| red cell diameter width (RDW, mean, inv-norm transformed) | 1e-323 | rs5756487 | 1 | GCST90476361 | no MR -> candidate analysis |
| Red cell distribution width | 1e-300 | rs5756487 | 1 | GCST007074 | no MR -> candidate analysis |
| CSF2RB protein levels | 1e-83 | rs11554714 | 3 | GCST90468883 | no MR -> candidate analysis |
| Red blood cell erythrocyte distribution width (UKB data fiel | 5e-16 | rs140768200 | 1 | GCST90468099 | no MR -> candidate analysis |
| Blood cell traits latent factor 2 (red cell) | 1e-15 | rs5756480 | 4 | GCST90559244 | no MR -> candidate analysis |
| Mean corpuscular haemoglobin (UKB data field 30050) | 5e-15 | rs141776099 | 1 | GCST90468084 | no MR -> candidate analysis |
| Protein quantitative trait loci (liver) | 5e-14 | rs11704682 | 1 | GCST011427 | no MR -> candidate analysis |
| Mean corpuscular volume (UKB data field 30040) | 8e-14 | rs141776099 | 1 | GCST90468086 | no MR -> candidate analysis |
| …and 5 more traits (see JSON) |
Top diseases by Open Targets association (of 168 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| COVID-19 | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| severe acute respiratory syndrome | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| atopic eczema | 0.165 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.066 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.062 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.062 | — | common-variant locus | no MR -> candidate analysis |
| poisoning | 0.062 | — | common-variant locus | no MR -> candidate analysis |
| narcolepsy | 0.046 | — | common-variant locus | no MR -> candidate analysis |
| Myoclonus | 0.046 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Thiosulfate sulfurtransferase) |
| gnomAD constraint | pLI=1.1e-08, LOEUF=1.54 — LoF-tolerant |
| GWAS Catalog | 147 unique SNPs / 382 rows |
| ClinVar | 76 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 168 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TST’ and resolved to ‘Thiosulfate sulfurtransferase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 76 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 17 of 17 traits by best p-value, aggregated from 25 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q16762 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000128311/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295835/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TST — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TST — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TST%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TST — GWAS Catalog search API (live; release not exposed)