MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis | 1.66 | 0.445 | 1.87e-04 | Wald ratio | 1 | trans | NA |
| Cigarettes smoked per day | 2.05 | 0.597 | 5.82e-04 | Wald ratio | 1 | trans | NA |
| Vascular or heart problems diagnosed by doctor: Angina | 0.104 | 0.0426 | 0.0145 | Wald ratio | 1 | trans | NA |
| Cancer code self-reported: prostate cancer | 0.192 | 0.0819 | 0.0189 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | 0.0848 | 0.0374 | 0.0234 | Wald ratio | 1 | trans | NA |
| Age at menopause | -0.302 | 0.134 | 0.0244 | Wald ratio | 1 | trans | NA |
| Birth weight | 0.0302 | 0.0134 | 0.0244 | Wald ratio | 1 | trans | NA |
| Lumbar spine bone mineral density | 0.0656 | 0.0313 | 0.0364 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.133 | 0.0653 | 0.0413 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | 0.131 | 0.0642 | 0.0418 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | 0.177 | 0.0873 | 0.0424 | Wald ratio | 1 | trans | NA |
| Subjective well being | -0.0268 | 0.0134 | 0.0455 | Wald ratio | 1 | trans | NA |
| …and 92 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
72 association rows across 52 traits (62 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-300 | rs116769360 | 1 | GCST90321120 | no MR -> candidate analysis |
| RWDD1/TXNDC5 protein level ratio | 2e-138 | rs11962800 | 1 | GCST90315796 | no MR -> candidate analysis |
| LGALS8/TXNDC5 protein level ratio | 5e-135 | rs11962800 | 1 | GCST90315321 | no MR -> candidate analysis |
| MCFD2/TXNDC5 protein level ratio | 5e-127 | rs11962800 | 1 | GCST90315410 | no MR -> candidate analysis |
| ENO2/TXNDC5 protein level ratio | 5e-108 | rs11962800 | 1 | GCST90314671 | no MR -> candidate analysis |
| CRELD2/TXNDC5 protein level ratio | 2e-96 | rs11962800 | 1 | GCST90314259 | no MR -> candidate analysis |
| NUCB2/TXNDC5 protein level ratio | 2e-95 | rs11962800 | 1 | GCST90315578 | no MR -> candidate analysis |
| PARK7/TXNDC5 protein level ratio | 9e-89 | rs11962800 | 1 | GCST90315600 | no MR -> candidate analysis |
| Circulating TXNDC5 levels | 1e-80 | rs111331197 | 3 | GCST90860383 | no MR -> candidate analysis |
| SEMA4D/TXNDC5 protein level ratio | 9e-79 | rs11962800 | 1 | GCST90315824 | no MR -> candidate analysis |
| LBR/TXNDC5 protein level ratio | 5e-77 | rs11962800 | 1 | GCST90315304 | no MR -> candidate analysis |
| PTPN6/TXNDC5 protein level ratio | 2e-74 | rs11962800 | 1 | GCST90315749 | no MR -> candidate analysis |
| …and 40 more traits (see JSON) |
Top diseases by Open Targets association (of 226 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| colorectal carcinoma | 0.48 | — | common-variant locus | no MR -> candidate analysis |
| spinal stenosis | 0.273 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.111 | — | common-variant locus | no MR -> candidate analysis |
| kidney cancer | 0.085 | — | common-variant locus | no MR -> candidate analysis |
| Abnormal nasolacrimal system morphology | 0.085 | — | common-variant locus | no MR -> candidate analysis |
| spermatocele | 0.072 | — | common-variant locus | no MR -> candidate analysis |
Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Thioredoxin domain-containing protein 5) |
| gnomAD constraint | pLI=3.8e-13, LOEUF=1.08 — LoF-tolerant |
| GWAS Catalog | 109 unique SNPs / 184 rows |
| ClinVar | 105 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 226 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TXNDC5’ and resolved to ‘Thioredoxin domain-containing protein 5’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 105 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 52 traits by best p-value, aggregated from 72 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8NBS9 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000239264/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4739698/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TXNDC5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TXNDC5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TXNDC5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TXNDC5 — GWAS Catalog search API (live; release not exposed)