Protein Dossier — TYRO3 (Tyrosine-protein kinase receptor TYRO3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diastolic blood pressure automated reading |
0.079 |
0.0169 |
3.03e-06 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0967 |
0.0256 |
1.58e-04 |
Wald ratio |
1 |
cis |
NA |
| Years of schooling |
-0.0932 |
0.0248 |
1.77e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
0.302 |
0.0858 |
4.22e-04 |
Wald ratio |
1 |
cis |
NA |
| Height |
-0.0683 |
0.0205 |
8.58e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.192 |
0.0609 |
0.00161 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
0.0678 |
0.0244 |
0.00551 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
0.464 |
0.172 |
0.00708 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
0.339 |
0.133 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Neuroticism |
0.0621 |
0.0248 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: small intestine or small bowel cancer |
0.901 |
0.37 |
0.0147 |
Wald ratio |
1 |
cis |
NA |
| Cigarettes smoked per day |
1.33 |
0.563 |
0.0183 |
Wald ratio |
1 |
cis |
NA |
| …and 69 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2611_72_2 |
Dtk |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
62 association rows across 50 traits (59 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating TYRO3 levels |
8e-2144 |
rs8025483 |
2 |
GCST90860397 |
no MR -> candidate analysis |
| TYRO3 protein levels |
1e-279 |
rs4924560 |
4 |
GCST90470997 |
no MR -> candidate analysis |
| Tyrosine-protein kinase receptor TYRO3 levels |
3e-87 |
rs11639399 |
2 |
GCST90179461 |
no MR -> candidate analysis |
| SPESP1 protein levels |
2e-67 |
rs8038764 |
1 |
GCST90470720 |
no MR -> candidate analysis |
| Standing height (UKB data field 50) |
3e-24 |
rs8023311 |
1 |
GCST90468178 |
no MR -> candidate analysis |
| HDL cholesterol levels |
6e-20 |
rs7170463 |
1 |
GCST010242 |
no MR -> candidate analysis |
| Haematocrit percentage (UKB data field 30030) |
1e-19 |
rs7170463 |
1 |
GCST90468073 |
no MR -> candidate analysis |
| Height |
4e-19 |
rs8036643 |
1 |
GCST90435412 |
MR: beta=-0.0683, p=8.58e-04 (cis) |
| Cholesteryl Esters in Medium HDL |
2e-17 |
rs7170463 |
1 |
GCST90501184 |
no MR -> candidate analysis |
| Free Cholesterol in HDL |
3e-17 |
rs7170463 |
1 |
GCST90501114 |
no MR -> candidate analysis |
| Cholesterol in Medium HDL |
3e-17 |
rs7170463 |
1 |
GCST90501182 |
no MR -> candidate analysis |
| High density lipoprotein cholesterol levels |
1e-16 |
rs7170463 |
2 |
GCST90239649 |
no MR -> candidate analysis |
| …and 38 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 491 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| metabolic syndrome |
0.569 |
— |
common-variant locus |
no MR -> candidate analysis |
| Moderate albuminuria |
0.48 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.477 |
— |
common-variant locus |
no MR -> candidate analysis |
| cardiac arrhythmia |
0.383 |
— |
common-variant locus |
no MR -> candidate analysis |
| intelligence |
0.287 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hereditary breast and ovarian cancer syndrome |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| hereditary breast ovarian cancer syndrome |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| 46,XX disorder of sex development |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.153 |
— |
common-variant locus |
no MR -> candidate analysis |
| albuminuria |
0.113 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 10 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Tyrosine-protein kinase receptor TYRO3) |
| gnomAD constraint |
pLI=0.56, LOEUF=0.523 — LoF-tolerant |
| GWAS Catalog |
101 unique SNPs / 199 rows |
| ClinVar |
152 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 491 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TYRO3’ and resolved to ‘Tyrosine-protein kinase receptor TYRO3’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 152 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 50 traits by best p-value, aggregated from 62 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q06418 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000092445/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5314/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TYRO3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TYRO3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TYRO3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TYRO3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:31:37 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none