MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Total cholesterol | 0.086 | 0.014 | 7.18e-10 | Wald ratio | 1 | cis | NA |
| LDL cholesterol | 0.0709 | 0.0147 | 1.43e-06 | Wald ratio | 1 | cis | NA |
| Thalamus volume | -78.2 | 25.6 | 0.00225 | Wald ratio | 1 | cis | NA |
| Triglycerides | 0.0377 | 0.0132 | 0.00427 | Wald ratio | 1 | cis | NA |
| Bipolar disorder | -0.26 | 0.0928 | 0.00502 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K80 Cholelithiasis | -0.242 | 0.0873 | 0.00562 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.258 | 0.0995 | 0.00942 | Wald ratio | 1 | cis | NA |
| Systemic lupus erythematosus | 0.445 | 0.187 | 0.0173 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: J33 Nasal polyp | 0.261 | 0.111 | 0.0187 | Wald ratio | 1 | cis | NA |
| HOMA-IR | 0.0366 | 0.0158 | 0.0209 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0322 | 0.0144 | 0.0258 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.0981 | 0.0453 | 0.0303 | Wald ratio | 1 | cis | NA |
| …and 103 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
541 association rows across 229 traits (529 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Total bilirubin levels | 3e-26677 | rs35754645 | 28 | GCST90018973 | no MR -> candidate analysis |
| Direct bilirubin levels | 9e-13050 | rs10929302 | 15 | GCST90019505 | no MR -> candidate analysis |
| Bilirubin (z,z) levels | 8e-957 | rs1976391 | 8 | GCST90245127 | no MR -> candidate analysis |
| Biliverdin levels | 2e-802 | rs1976391 | 10 | GCST90245128 | no MR -> candidate analysis |
| Bilirubin (E,E) levels | 6e-774 | rs1976391 | 7 | GCST90245126 | no MR -> candidate analysis |
| X-11530 levels | 1e-542 | rs1976391 | 6 | GCST90245503 | no MR -> candidate analysis |
| X-11522 levels | 3e-541 | rs1976391 | 4 | GCST90245502 | no MR -> candidate analysis |
| Bilirubin degradation product, C17H18N2O4 (3) levels | 2e-366 | rs887829 | 1 | GCST90200703 | no MR -> candidate analysis |
| X-16946 levels | 2e-363 | rs887829 | 4 | GCST90245615 | no MR -> candidate analysis |
| Succinimide levels | 4e-333 | rs887829 | 2 | GCST90245438 | no MR -> candidate analysis |
| Bilirubin levels | 5e-324 | rs6742078 | 20 | GCST000386 | no MR -> candidate analysis |
| Bilirubin degradation product, C16H18N2O5 (3) levels | 2e-308 | rs887829 | 1 | GCST90200271 | no MR -> candidate analysis |
| …and 217 more traits (see JSON) |
Top diseases by Open Targets association (of 234 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Gilbert syndrome | 0.763 | 0.28 | established (curated) | no MR -> candidate analysis |
| porphyrin metabolism disease | 0.749 | 0.862 | multi-layer: burden+GWAS (allelic-series candidate) | no MR -> candidate analysis |
| Crigler-Najjar syndrome type 1 | 0.931 | — | established (curated) | no MR -> candidate analysis |
| Crigler-Najjar syndrome type 2 | 0.928 | — | established (curated) | no MR -> candidate analysis |
| transient familial neonatal hyperbilirubinemia | 0.917 | — | established (curated) | no MR -> candidate analysis |
| Hyperbilirubinemia | 0.73 | — | established (curated) | no MR -> candidate analysis |
| Crigler-Najjar syndrome | 0.9 | — | established (curated) | no MR -> candidate analysis |
| bilirubin metabolism disease | 0.708 | 0.775 | multi-layer: burden+GWAS (allelic-series candidate) | no MR -> candidate analysis |
| hereditary disease | 0.841 | — | established (curated) | no MR -> candidate analysis |
| cholelithiasis | 0.684 | — | common-variant locus | MR: beta=-0.242, p=0.00562 (cis) |
| Cholecystitis | 0.533 | — | common-variant locus | no MR -> candidate analysis |
| Jaundice | 0.487 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| gallstones | 0.47 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes mellitus | 0.443 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 2 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (UDP-glucuronosyltransferase 1A6) |
| gnomAD constraint | pLI=1.8e-08, LOEUF=0.969 — LoF-tolerant |
| GWAS Catalog | 302 unique SNPs / 832 rows |
| ClinVar | 639 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 16 clinical annotations across 11 drugs |
phenome — Top 30 of 234 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘UGT1A6’ and resolved to ‘UDP-glucuronosyltransferase 1A6’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 639 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 229 traits by best p-value, aggregated from 541 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P19224 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000167165/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1743316/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/UGT1A6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/UGT1A6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=UGT1A6%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=UGT1A6 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/UGT1A6 — GWAS Catalog search API (live; release not exposed)