Protein Dossier — ULBP3 (UL16-binding protein 3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Alcohol intake frequency |
-0.0739 |
0.025 |
0.00308 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.335 |
0.116 |
0.00372 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.0585 |
0.0205 |
0.00427 |
Wald ratio |
1 |
cis |
NA |
| Fasting glucose |
0.0497 |
0.0216 |
0.0216 |
Wald ratio |
1 |
cis |
NA |
| 2hr glucose |
0.304 |
0.135 |
0.0238 |
Wald ratio |
1 |
cis |
NA |
| Neo-openness to experience |
1.09 |
0.492 |
0.0264 |
Wald ratio |
1 |
cis |
NA |
| Caudate volume |
72.7 |
33.2 |
0.0284 |
Wald ratio |
1 |
cis |
NA |
| Urate |
0.0819 |
0.0386 |
0.0339 |
Wald ratio |
1 |
cis |
NA |
| Large vessel disease |
0.489 |
0.239 |
0.0407 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
0.239 |
0.124 |
0.055 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0523 |
0.0274 |
0.0558 |
Wald ratio |
1 |
cis |
NA |
| Knee osteoarthritis |
0.362 |
0.191 |
0.0578 |
Wald ratio |
1 |
cis |
NA |
| …and 80 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2747_3_2 |
ULBP-3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
22 association rows across 18 traits (13 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| NKG2D ligand 3 levels |
1e-106 |
rs6918234 |
1 |
GCST90425447 |
no MR -> candidate analysis |
| ULBP2 protein levels |
2e-41 |
rs116968353 |
3 |
GCST90471008 |
no MR -> candidate analysis |
| LRP11 protein levels |
4e-28 |
rs9383665 |
1 |
GCST90469796 |
no MR -> candidate analysis |
| SH2 domain-containing adapter protein D levels |
3e-11 |
rs12662494 |
1 |
GCST90424770 |
no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia |
6e-10 |
rs7769185; rs7764312; rs1999670; rs1107835; rs9383690; rs1408505 |
2 |
GCST008413 |
no MR -> candidate analysis |
| Blood protein levels |
2e-9 |
rs17054300 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Eosinophil count |
3e-8 |
rs10428766 |
1 |
GCST007065 |
no MR -> candidate analysis |
| Gut microbiome abundance (class Bacteroides sp. 8 (at 1 year |
3e-8 |
rs6922684 |
1 |
GCST90568729 |
no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) |
3e-8 |
rs912558 x rs6941758 |
1 |
GCST010340 |
no MR -> candidate analysis |
| Pain intensity in opioid-treated advanced cancer |
3e-7 |
rs9479734 |
1 |
GCST90435150 |
no MR -> candidate analysis |
| Gut microbiome abundance (class Tyzzerella sp. 3 (at 3 month |
3e-7 |
rs75811154 |
1 |
GCST90568675 |
no MR -> candidate analysis |
| Cerebral amyloid angiopathy x APOEe4 status interaction in A |
5e-7 |
rs13207159 |
1 |
GCST012484 |
no MR -> candidate analysis |
| …and 6 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 92 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| esophageal ulcer |
0.404 |
— |
common-variant locus |
no MR -> candidate analysis |
| self-injurious ideation |
0.343 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=3e-09, LOEUF=1.4 — LoF-tolerant |
| GWAS Catalog |
71 unique SNPs / 129 rows |
| ClinVar |
59 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 92 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ULBP3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 59 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 18 of 18 traits by best p-value, aggregated from 22 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9BZM4 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000131019/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ULBP3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ULBP3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ULBP3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ULBP3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:32:49 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none