Protein Dossier — UNC5C (Netrin receptor UNC5C)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Forearm bone mineral density |
-0.113 |
0.0644 |
0.08 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.033 |
0.0271 |
0.223 |
Wald ratio |
1 |
cis |
NA |
| ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0367 |
0.0323 |
0.255 |
Wald ratio |
1 |
cis |
NA |
| Low grade serous ovarian cancer |
-0.186 |
0.196 |
0.341 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
0.0914 |
0.117 |
0.436 |
Wald ratio |
1 |
cis |
NA |
| Clear cell ovarian cancer |
-0.111 |
0.164 |
0.497 |
Wald ratio |
1 |
cis |
NA |
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5139_32_3 |
UNC5H3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
90 association rows across 66 traits (58 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Netrin receptor UNC5C levels |
9e-55 |
rs13134684 |
3 |
GCST90248759 |
no MR -> candidate analysis |
| Netrin receptor UNC5B levels |
7e-31 |
rs61432083 |
2 |
GCST90248758 |
no MR -> candidate analysis |
| Netrin receptor UNC5C levels (UNC5C.5139.32.3) |
2e-25 |
rs57091121 |
2 |
GCST90242044 |
no MR -> candidate analysis |
| Metabolic syndrome |
1e-20 |
rs3775002 |
3 |
GCST90444487 |
no MR -> candidate analysis |
| Serum levels of protein UNC5C |
5e-18 |
rs35063103 |
1 |
GCST90088952 |
no MR -> candidate analysis |
| GLIPR1 protein levels |
5e-16 |
rs151067671 |
1 |
GCST90469357 |
no MR -> candidate analysis |
| Cerebellar grey matter morphology (MOSTest) |
3e-13 |
rs10026552 |
1 |
GCST90728589 |
no MR -> candidate analysis |
| Body mass index |
6e-13 |
rs10856911 |
10 |
GCST90662912 |
no MR -> candidate analysis |
| Systolic blood pressure |
1e-12 |
rs35508536 |
1 |
GCST90435415 |
no MR -> candidate analysis |
| Netrin receptor UNC5B (analyte X7776.20) levels |
1e-12 |
rs13118653 |
1 |
GCST90427061 |
no MR -> candidate analysis |
| Blood protein levels |
2e-11 |
rs10030217 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Type 2 diabetes |
2e-11 |
rs2289043 |
5 |
GCST90492734 |
no MR -> candidate analysis |
| …and 54 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1812 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| type 2 diabetes mellitus |
0.72 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.67 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypertensive disorder |
0.652 |
— |
common-variant locus |
no MR -> candidate analysis |
| angina pectoris |
0.627 |
— |
common-variant locus |
no MR -> candidate analysis |
| myocardial ischemia |
0.597 |
— |
common-variant locus |
no MR -> candidate analysis |
| bilirubin metabolism disease |
0.537 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetic ketoacidosis |
0.523 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hypocalcemia |
0.523 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian dysfunction |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental retention |
0.51 |
— |
common-variant locus |
no MR -> candidate analysis |
| appendicitis |
0.51 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental abruption |
0.497 |
— |
common-variant locus |
no MR -> candidate analysis |
| placenta praevia |
0.485 |
— |
common-variant locus |
no MR -> candidate analysis |
| fracture of pelvis |
0.485 |
— |
common-variant locus |
no MR -> candidate analysis |
| device complication |
0.485 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.00019, LOEUF=0.601 — LoF-tolerant |
| GWAS Catalog |
117 unique SNPs / 197 rows |
| ClinVar |
190 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1812 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘UNC5C’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 190 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 66 traits by best p-value, aggregated from 90 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O95185 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000182168/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/UNC5C — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/UNC5C — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=UNC5C%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/UNC5C — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:33:00 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none