MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Platelet count | -10.3 | 3.2 | 0.00135 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | 0.236 | 0.0787 | 0.00277 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | 0.0738 | 0.0268 | 0.00596 | Wald ratio | 1 | cis | NA |
| Lumbar spine bone mineral density | -0.17 | 0.0651 | 0.00919 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.248 | 0.106 | 0.0195 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | -0.267 | 0.115 | 0.0202 | Wald ratio | 1 | cis | NA |
| Schizophrenia | 0.189 | 0.0819 | 0.0213 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0623 | 0.0283 | 0.0278 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | 0.208 | 0.0953 | 0.0292 | Wald ratio | 1 | cis | NA |
| Potassium in urine | 0.0387 | 0.0179 | 0.0309 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.185 | 0.0866 | 0.033 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Cataract | 0.171 | 0.082 | 0.0373 | Wald ratio | 1 | cis | NA |
| …and 105 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
79 association rows across 49 traits (49 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Uronyl 2-sulfotransferase levels | 2e-102 | rs11757768 | 3 | GCST90250050 | no MR -> candidate analysis |
| Atrial fibrillation | 4e-55 | rs117984853 | 7 | GCST90624412 | MR: beta=0.154, p=0.293 (cis) |
| Height | 1e-54 | rs2153252 | 13 | GCST90245848 | MR: beta=0.0436, p=0.0559 (cis) |
| LRP11 protein levels | 3e-33 | rs34245267 | 2 | GCST90469796 | no MR -> candidate analysis |
| Atrial fibrillation (MTAG) | 1e-23 | rs117984853 | 4 | GCST90132229 | no MR -> candidate analysis |
| Peak expiratory flow | 1e-18 | rs4336467 | 1 | GCST90244095 | no MR -> candidate analysis |
| Atrial fibrillation/atrial flutter | 2e-16 | rs117984853 | 1 | GCST90018796 | no MR -> candidate analysis |
| Peak expiratory flow (UKB data field 3064) | 2e-13 | rs3949414 | 1 | GCST90468176 | no MR -> candidate analysis |
| Serum levels of protein UST | 1e-12 | rs11155591 | 1 | GCST90090156 | no MR -> candidate analysis |
| ULBP2 protein levels | 2e-12 | rs142525075 | 1 | GCST90471008 | no MR -> candidate analysis |
| Exophthalmos (PheCode 242.3) | 2e-11 | rs140924397 | 1 | GCST90479865 | no MR -> candidate analysis |
| ViT-derived brain MRI phenotypes (128-dimensional ViT-UDIPs; | 5e-11 | rs2486411 | 1 | GCST90841192 | no MR -> candidate analysis |
| …and 37 more traits (see JSON) |
Top diseases by Open Targets association (of 91 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| atrial fibrillation | 0.576 | — | common-variant locus | MR: beta=0.154, p=0.293 (cis) |
| non-autoimmune hemolytic anemia | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| open-angle glaucoma | 0.516 | — | common-variant locus | no MR -> candidate analysis |
| amyotrophic lateral sclerosis | 0.502 | — | common-variant locus | no MR -> candidate analysis |
| hypothyroidism | 0.499 | — | common-variant locus | MR: beta=0.097, p=0.175 (cis) |
| pneumonitis | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| ulcerative colitis | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| Dupuytren Contracture | 0.437 | — | common-variant locus | no MR -> candidate analysis |
| protozoa infectious disease | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| self-injurious ideation | 0.366 | — | common-variant locus | no MR -> candidate analysis |
| myasthenia gravis | 0.356 | — | common-variant locus | no MR -> candidate analysis |
| heart disorder | 0.353 | — | common-variant locus | no MR -> candidate analysis |
| contact dermatitis | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.328 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the immune system | 0.325 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.025, LOEUF=0.664 — LoF-tolerant |
| GWAS Catalog | 66 unique SNPs / 119 rows |
| ClinVar | 76 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 91 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘UST’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 76 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 49 traits by best p-value, aggregated from 79 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9Y2C2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000111962/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/UST — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/UST — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=UST%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=UST — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/UST — GWAS Catalog search API (live; release not exposed)