Protein Dossier — VCAM1 (Vascular cell adhesion protein 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.74 |
0.0273 |
1.92e-161 |
Wald ratio |
1 |
trans |
0.997 |
| Diastolic blood pressure automated reading |
0.205 |
0.0132 |
1.66e-54 |
Wald ratio |
1 |
trans |
0.994 |
| Non-cancer illness code self-reported: hypertension |
0.214 |
0.0177 |
1.53e-33 |
Wald ratio |
1 |
trans |
0.994 |
| Platelet count |
21.9 |
2.21 |
3.64e-23 |
Wald ratio |
1 |
trans |
0.997 |
| Haemoglobin concentration |
0.273 |
0.0306 |
3.64e-19 |
Wald ratio |
1 |
trans |
NA |
| Systolic blood pressure automated reading |
0.115 |
0.0132 |
2.52e-18 |
Wald ratio |
1 |
trans |
0.993 |
| Total cholesterol |
-0.171 |
0.0198 |
8.36e-18 |
Wald ratio |
1 |
trans |
0.998 |
| Packed cell volume |
0.779 |
0.0949 |
2.34e-16 |
Wald ratio |
1 |
trans |
NA |
| Red blood cell count |
0.0858 |
0.0118 |
3.52e-13 |
Wald ratio |
1 |
trans |
NA |
| HDL cholesterol |
-0.138 |
0.0193 |
7.68e-13 |
Wald ratio |
1 |
trans |
0.997 |
| LDL cholesterol |
-0.144 |
0.0204 |
1.76e-12 |
Wald ratio |
1 |
trans |
0.997 |
| Non-cancer illness code self-reported: psoriasis |
0.501 |
0.074 |
1.36e-11 |
Wald ratio |
1 |
trans |
0.992 |
| …and 130 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2967_8_1 |
VCAM-1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
63 association rows across 39 traits (57 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Hematological traits (multi-trait analysis) |
2e-78 |
rs6684679 |
2 |
GCST90838669 |
no MR -> candidate analysis |
| Lymphocyte count (UKB data field 30120) |
5e-49 |
rs2148404 |
2 |
GCST90468082 |
no MR -> candidate analysis |
| Circulating VCAM1 levels |
1e-42 |
rs139561173 |
2 |
GCST90860455 |
no MR -> candidate analysis |
| VCAM1 protein levels |
7e-39 |
rs12240047 |
2 |
GCST90471031 |
no MR -> candidate analysis |
| Lymphocyte count |
1e-38 |
rs12088882 |
4 |
GCST90085815 |
no MR -> candidate analysis |
| Platelet-to-lymphocyte ratio |
1e-35 |
rs12047102 |
1 |
GCST90056184 |
no MR -> candidate analysis |
| monocyte (absolute count, mean, inv-norm transformed) |
1e-31 |
rs78453488 |
1 |
GCST90475502 |
no MR -> candidate analysis |
| Monocyte count |
3e-30 |
rs71660930 |
3 |
GCST90002393 |
no MR -> candidate analysis |
| lymphocyte (absolute count, maximum, inv-norm transformed) |
1e-29 |
rs1409425 |
1 |
GCST90479663 |
no MR -> candidate analysis |
| lymphocyte (absolute count, mean, inv-norm transformed) |
2e-28 |
rs11166512 |
1 |
GCST90479664 |
no MR -> candidate analysis |
| Monocyte count (UKB data field 30130) |
7e-26 |
rs71660930 |
1 |
GCST90468090 |
no MR -> candidate analysis |
| Lymphocyte percentage (UKB data field 30180) |
6e-24 |
rs10875333 |
1 |
GCST90468083 |
no MR -> candidate analysis |
| …and 27 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1289 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| open-angle glaucoma |
0.55 |
— |
common-variant locus |
no MR -> candidate analysis |
| glaucoma |
0.459 |
— |
common-variant locus |
MR: beta=-0.231, p=0.0954 (trans) |
| Crohn disease |
0.346 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Vascular cell adhesion protein 1) |
| gnomAD constraint |
pLI=5e-09, LOEUF=0.833 — LoF-tolerant |
| GWAS Catalog |
55 unique SNPs / 110 rows |
| ClinVar |
114 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1289 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘VCAM1’ and resolved to ‘Vascular cell adhesion protein 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 114 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 39 traits by best p-value, aggregated from 63 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P19320 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162692/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3735/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/VCAM1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VCAM1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VCAM1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/VCAM1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:34:40 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none