MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Body mass index (BMI) |
-0.00885 |
0.00344 |
0.01 |
Wald ratio |
1 |
cis |
NA |
| Bulimia nervosa |
-0.0256 |
0.00997 |
0.0101 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
-0.0396 |
0.016 |
0.0131 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
0.0636 |
0.0261 |
0.0147 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting |
-0.153 |
0.0641 |
0.0167 |
Wald ratio |
1 |
cis |
NA |
| Knee and hip osteoarthritis |
0.073 |
0.0306 |
0.017 |
Wald ratio |
1 |
cis |
NA |
| Neo-agreeableness |
0.219 |
0.092 |
0.0173 |
Wald ratio |
1 |
cis |
NA |
| Haemoglobin concentration |
0.0209 |
0.00883 |
0.0177 |
Wald ratio |
1 |
cis |
NA |
| Birth length |
0.0322 |
0.015 |
0.0314 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
0.0309 |
0.0145 |
0.033 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
-0.0279 |
0.0135 |
0.0388 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse |
0.087 |
0.0428 |
0.042 |
Wald ratio |
1 |
cis |
NA |
| …and 100 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2597_8_3 |
VEGF |
Suhre K |
2019 |
prot-c-4867_15_2 |
VEGF121 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
1384 association rows across 677 traits (1328 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Thyroid stimulating hormone levels |
1e-336 |
rs2396083 |
7 |
GCST90572789 |
no MR -> candidate analysis |
| Waist-to-hip ratio adjusted for BMI |
3e-168 |
rs998584 |
43 |
GCST008733 |
no MR -> candidate analysis |
| Triglyceride levels |
8e-159 |
rs998584 |
26 |
GCST90239661 |
no MR -> candidate analysis |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm t |
2e-145 |
rs998584 |
3 |
GCST90475352 |
no MR -> candidate analysis |
| Waist-hip ratio |
3e-145 |
rs998584 |
17 |
GCST007067 |
no MR -> candidate analysis |
| triglyceride (mean, inv-norm transformed) |
3e-144 |
rs998584 |
3 |
GCST90476435 |
no MR -> candidate analysis |
| Waist-hip index |
7e-138 |
rs998584 |
18 |
GCST90020027 |
no MR -> candidate analysis |
| A body shape index |
6e-129 |
rs998584 |
16 |
GCST90020024 |
no MR -> candidate analysis |
| high density lipoprotein cholesterol (HDLC, minimm, inv-norm |
9e-129 |
rs998584 |
3 |
GCST90475356 |
no MR -> candidate analysis |
| triglyceride (maximum, inv-norm transformed) |
7e-127 |
rs998584 |
2 |
GCST90476431 |
no MR -> candidate analysis |
| high density lipoprotein cholesterol (HDLC, maximum, inv-nor |
8e-126 |
rs998584 |
3 |
GCST90475348 |
no MR -> candidate analysis |
| Cholesteryl Esters in Large HDL |
2e-123 |
rs998584 |
2 |
GCST90501136 |
no MR -> candidate analysis |
| …and 665 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 6064 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| diabetic retinopathy |
0.069 |
— |
common-variant locus |
no MR -> candidate analysis |
| wet macular degeneration |
0.068 |
— |
common-variant locus |
no MR -> candidate analysis |
| breast cancer |
0.056 |
— |
common-variant locus |
MR: beta=0.0242, p=0.184 (cis) |
| macular degeneration |
0.078 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
13 known modulators (Vascular endothelial growth factor A, long form) |
| gnomAD constraint |
pLI=0.4, LOEUF=0.585 — LoF-tolerant |
| GWAS Catalog |
122 unique SNPs / 294 rows |
| ClinVar |
126 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
28 clinical annotations across 17 drugs |
phenome — Top 30 of 6064 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘VEGFA’ and resolved to ‘Vascular endothelial growth factor A, long form’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 126 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 677 traits by best p-value, aggregated from 1384 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P15692 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000112715/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1783/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/VEGFA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VEGFA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VEGFA%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=VEGFA — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/VEGFA — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:34:58 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none