Protein Dossier — VEGFC (Vascular endothelial growth factor C)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: joint disorder |
0.213 |
0.0813 |
0.00875 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K35 Acute appendicitis |
0.206 |
0.0805 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0281 |
0.0113 |
0.0131 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast |
0.114 |
0.0478 |
0.0175 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.233 |
0.104 |
0.0254 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
-0.0683 |
0.0319 |
0.0321 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis |
0.106 |
0.0534 |
0.0466 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: malignant melanoma |
0.125 |
0.0688 |
0.0684 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0324 |
0.0186 |
0.081 |
Wald ratio |
1 |
cis |
NA |
| Fracture resulting from simple fall |
0.0301 |
0.018 |
0.0944 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
0.00868 |
0.00534 |
0.104 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
-0.194 |
0.123 |
0.114 |
Wald ratio |
1 |
cis |
NA |
| …and 46 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3132_1_1 |
VEGF-C |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
42 association rows across 28 traits (37 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Serum levels of protein VEGFC |
5e-240 |
rs41278571 |
1 |
GCST90088234 |
no MR -> candidate analysis |
| Blood protein levels |
1e-117 |
rs112782083 |
1 |
GCST006585 |
no MR -> candidate analysis |
| VEGFC protein levels |
6e-89 |
rs35029317 |
2 |
GCST90471036 |
no MR -> candidate analysis |
| Vascular endothelial growth factor C levels (VEGFC.3132.1.1) |
1e-46 |
rs41278571 |
1 |
GCST90243320 |
no MR -> candidate analysis |
| DKK1/VEGFC protein level ratio |
1e-27 |
rs10020321 |
1 |
GCST90314484 |
no MR -> candidate analysis |
| Thyroid stimulating hormone levels |
2e-24 |
rs4571283 |
4 |
GCST90572789 |
no MR -> candidate analysis |
| Hypothyroidism (PheCode 244) |
2e-22 |
rs4690362 |
2 |
GCST90475647 |
no MR -> candidate analysis |
| Hypothyroidism |
3e-22 |
rs4690362 |
3 |
GCST90627749 |
MR: beta=-0.0226, p=0.468 (cis) |
| Hypothyroidism NOS (PheCode 244.4) |
4e-21 |
rs4690362 |
2 |
GCST90475653 |
no MR -> candidate analysis |
| Appendicular lean mass |
7e-18 |
rs6552198 |
1 |
GCST90000025 |
no MR -> candidate analysis |
| Vascular endothelial growth factor C levels |
1e-17 |
rs112793547 |
1 |
GCST90250161 |
no MR -> candidate analysis |
| Total testosterone levels |
6e-15 |
rs371162363 |
2 |
GCST90012112 |
no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 760 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Milroy disease |
0.727 |
— |
established (curated) |
no MR -> candidate analysis |
| hypothyroidism |
0.872 |
— |
common-variant locus |
MR: beta=-0.0226, p=0.468 (cis) |
| Abnormality of the skeletal system |
0.784 |
— |
common-variant locus |
no MR -> candidate analysis |
| thyroid gland disorder |
0.673 |
— |
common-variant locus |
no MR -> candidate analysis |
| Alzheimer disease |
0.52 |
— |
common-variant locus |
no MR -> candidate analysis |
| stroke disorder |
0.419 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.434 |
— |
common-variant locus |
no MR -> candidate analysis |
| benign neoplasm |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| male reproductive organ cancer |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| jaw disease |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| exostosis |
0.394 |
— |
common-variant locus |
no MR -> candidate analysis |
| brain aneurysm |
0.348 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic intestinal vascular insufficiency |
0.33 |
— |
common-variant locus |
no MR -> candidate analysis |
| hereditary disease |
0.316 |
— |
established (curated) |
no MR -> candidate analysis |
| adolescent idiopathic scoliosis |
0.272 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Vascular endothelial growth factor C) |
| gnomAD constraint |
pLI=1, LOEUF=0.422 — LoF-INTOLERANT |
| GWAS Catalog |
42 unique SNPs / 81 rows |
| ClinVar |
184 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 760 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘VEGFC’ and resolved to ‘Vascular endothelial growth factor C’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 184 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 42 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P49767 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000150630/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3714157/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/VEGFC — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VEGFC — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VEGFC%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/VEGFC — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:35:14 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none