MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.442 | 0.123 | 3.12e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | 0.134 | 0.0424 | 0.00155 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.175 | 0.0596 | 0.00324 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0217 | 0.00736 | 0.00326 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K44 Diaphragmatic hernia | 0.151 | 0.0517 | 0.00354 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | -0.0835 | 0.0288 | 0.00373 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.131 | 0.0501 | 0.0091 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: basal cell carcinoma | -0.269 | 0.104 | 0.00937 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Ankle | 0.143 | 0.0556 | 0.0103 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hiatus hernia | 0.112 | 0.044 | 0.0108 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | 0.0753 | 0.0335 | 0.0245 | Wald ratio | 1 | cis | NA |
| Percent emphysema | 0.0789 | 0.0351 | 0.0247 | Wald ratio | 1 | cis | NA |
| …and 79 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
102 association rows across 59 traits (88 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| VIT protein levels | 2e-158 | rs57817021 | 17 | GCST90471041 | no MR -> candidate analysis |
| Vitrin (analyte X6234.74) levels | 3e-135 | rs1468810 | 1 | GCST90426603 | no MR -> candidate analysis |
| Vitrin levels | 6e-113 | rs1468810 | 4 | GCST90250176 | no MR -> candidate analysis |
| Vitrin (analyte X9627.15) levels | 5e-105 | rs11124542 | 1 | GCST90427878 | no MR -> candidate analysis |
| Cerebrospinal fluid protein VIT levels | 1e-93 | rs11124542 | 1 | GCST90944656 | no MR -> candidate analysis |
| Vertex-wise cortical thickness | 4e-86 | rs13021393 | 1 | GCST90095131 | no MR -> candidate analysis |
| Serum levels of protein VIT | 6e-50 | rs1468810 | 4 | GCST90089312 | no MR -> candidate analysis |
| Brain shape (segment 1) | 8e-44 | rs35050623 | 1 | GCST90012880 | no MR -> candidate analysis |
| Vitrin levels (VIT.6234.74.3) | 2e-39 | rs10490666 | 3 | GCST90243345 | no MR -> candidate analysis |
| Height | 1e-33 | rs10490666 | 4 | GCST90245848 | MR: beta=-0.0196, p=0.0393 (cis) |
| Blood protein levels | 1e-26 | rs1468810 | 2 | GCST006585 | no MR -> candidate analysis |
| Sodium-independent sulfate anion transporter levels | 2e-19 | rs13019689 | 1 | GCST90422184 | no MR -> candidate analysis |
| …and 47 more traits (see JSON) |
Top diseases by Open Targets association (of 158 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| alcohol drinking | 0.636 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.59 | — | common-variant locus | no MR -> candidate analysis |
| multiple sclerosis | 0.508 | — | common-variant locus | no MR -> candidate analysis |
| acute tonsillitis | 0.505 | — | common-variant locus | no MR -> candidate analysis |
| squamous cell carcinoma | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| tinea unguium | 0.438 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.438 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.435 | — | common-variant locus | no MR -> candidate analysis |
| occlusion precerebral artery | 0.424 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.261 | — | common-variant locus | no MR -> candidate analysis |
| peripheral vascular disease | 0.068 | — | common-variant locus | no MR -> candidate analysis |
Of the 11 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Inter-alpha-trypsin inhibitor heavy chain H2) |
| gnomAD constraint | pLI=2.6e-41, LOEUF=1.5 — LoF-tolerant |
| GWAS Catalog | 100 unique SNPs / 212 rows |
| ClinVar | 186 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 158 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘VIT’ and resolved to ‘Inter-alpha-trypsin inhibitor heavy chain H2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 186 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 59 traits by best p-value, aggregated from 102 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q6UXI7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000205221/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295727/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/VIT — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VIT — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VIT%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/VIT — GWAS Catalog search API (live; release not exposed)