MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Height | -0.0438 | 0.0126 | 4.92e-04 | Wald ratio | 1 | trans | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.023 | 0.00864 | 0.00779 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | -0.593 | 0.223 | 0.0079 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.201 | 0.0778 | 0.0098 | Wald ratio | 1 | trans | NA |
| Fractured bone site(s): Wrist | 0.153 | 0.0615 | 0.013 | Wald ratio | 1 | trans | NA |
| Bipolar disorder | 0.245 | 0.102 | 0.0167 | Wald ratio | 1 | trans | NA |
| Cigarettes smoked per day | 0.827 | 0.349 | 0.0178 | Wald ratio | 1 | trans | NA |
| Myocardial infarction | 0.1 | 0.0426 | 0.0187 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | -0.0186 | 0.00819 | 0.0234 | Wald ratio | 1 | trans | NA |
| Body mass index (BMI) | 0.0224 | 0.00999 | 0.0253 | Wald ratio | 1 | trans | NA |
| Diastolic blood pressure automated reading | -0.021 | 0.0102 | 0.0405 | Wald ratio | 1 | trans | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.215 | 0.105 | 0.0413 | Wald ratio | 1 | trans | NA |
| …and 83 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
14 association rows across 10 traits (13 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| VSIG2 protein levels | 3e-178 | rs11604175 | 1 | GCST90471051 | no MR -> candidate analysis |
| Circulating ESAM levels | 1e-96 | rs11219769 | 1 | GCST90860618 | no MR -> candidate analysis |
| Serum levels of protein ESAM | 2e-32 | rs11604175 | 2 | GCST90088164 | no MR -> candidate analysis |
| Blood protein levels | 5e-22 | rs11604175 | 2 | GCST006585 | no MR -> candidate analysis |
| Endothelial cell-selective adhesion molecule levels (ESAM.78 | 4e-17 | rs11219769 | 1 | GCST90241050 | no MR -> candidate analysis |
| Endothelial cell-selective adhesion molecule levels | 4e-15 | rs561529099 | 3 | GCST90247390 | no MR -> candidate analysis |
| V-set and immunoglobulin domain-containing protein 2 levels | 5e-14 | rs11604175 | 1 | GCST90179466 | no MR -> candidate analysis |
| Diastolic blood pressure | 2e-9 | rs11604175 | 1 | GCST90310295 | MR: beta=-0.021, p=0.0405 (trans) |
| Irritable bowel syndrome or schizophrenia (pleiotropy) | 1e-8 | rs11604175 | 1 | GCST90271327 | no MR -> candidate analysis |
| Systolic blood pressure | 9e-6 | rs11604175 | 1 | GCST90310294 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 92 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| schizophrenia | 0.69 | — | common-variant locus | no MR -> candidate analysis |
| irritable bowel syndrome | 0.534 | — | common-variant locus | no MR -> candidate analysis |
| autism spectrum disorder | 0.144 | — | common-variant locus | no MR -> candidate analysis |
| anorexia nervosa | 0.134 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.131 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.126 | — | common-variant locus | no MR -> candidate analysis |
| Tourette syndrome | 0.115 | — | common-variant locus | no MR -> candidate analysis |
| bipolar disorder | 0.115 | — | common-variant locus | MR: beta=0.245, p=0.0167 (trans) |
| intelligence | 0.115 | — | common-variant locus | MR: beta=-0.0803, p=0.135 (trans) |
| obsessive-compulsive disorder | 0.115 | — | common-variant locus | no MR -> candidate analysis |
| major depressive disorder | 0.115 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.077 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.064 | — | common-variant locus | no MR -> candidate analysis |
| substance abuse | 0.044 | — | common-variant locus | no MR -> candidate analysis |
| frozen shoulder | 0.037 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=4.8e-11, LOEUF=1.38 — LoF-tolerant |
| GWAS Catalog | 38 unique SNPs / 76 rows |
| ClinVar | 141 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 92 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘VSIG2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 141 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 10 of 10 traits by best p-value, aggregated from 14 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q96IQ7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000019102/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/VSIG2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VSIG2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VSIG2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/VSIG2 — GWAS Catalog search API (live; release not exposed)