MR feasibility tier: C — No plasma pQTL found (accession + symbol match). Standard plasma pQTL MR is not currently feasible; gene-level genetic evidence below is the honest preview.
None in the EpiGraphDB pQTL resource. Absence of an estimate is not evidence of no effect.
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
2142 association rows across 1478 traits (2134 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Vitronectin levels | 4e-6996 | rs704 | 2 | GCST90250177 | no MR -> candidate analysis |
| MICOS complex subunit MIC10 levels | 4e-5900 | rs704 | 1 | GCST90248470 | no MR -> candidate analysis |
| MAP kinase-activated protein kinase 5 levels | 8e-3943 | rs704 | 1 | GCST90248480 | no MR -> candidate analysis |
| Transmembrane protease serine 6 levels | 7e-3426 | rs704 | 1 | GCST90249925 | no MR -> candidate analysis |
| Methyl-CpG-binding domain protein 1 levels | 8e-2008 | rs704 | 1 | GCST90248454 | no MR -> candidate analysis |
| MICOS complex subunit MIC10 levels (MINOS1.7956.11.3) | 1e-1442 | rs704 | 1 | GCST90241930 | no MR -> candidate analysis |
| Blood protein levels | 9e-1306 | rs704 | 589 | GCST006585 | no MR -> candidate analysis |
| Vitronectin (analyte X13125.45) levels | 5e-987 | rs704 | 1 | GCST90422096 | no MR -> candidate analysis |
| Carboxypeptidase N subunit 2 levels | 2e-846 | rs704 | 2 | GCST90246881 | no MR -> candidate analysis |
| Inactive peptidyl-prolyl cis-trans isomerase FKBP6 levels (F | 2e-836 | rs704 | 1 | GCST90241487 | no MR -> candidate analysis |
| Vitronectin levels (VTN.8280.238.3) | 8e-770 | rs704 | 1 | GCST90243346 | no MR -> candidate analysis |
| GTP-binding protein GEM levels | 2e-688 | rs704 | 1 | GCST90247828 | no MR -> candidate analysis |
| …and 1466 more traits (see JSON) |
Top diseases by Open Targets association (of 722 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hypertensive disorder | 0.715 | — | common-variant locus | no MR -> candidate analysis |
| temporal arteritis | 0.572 | — | common-variant locus | no MR -> candidate analysis |
| age-related macular degeneration | 0.426 | — | common-variant locus | no MR -> candidate analysis |
| ventricular septal defect | 0.451 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.408 | — | common-variant locus | no MR -> candidate analysis |
| wet macular degeneration | 0.3 | — | common-variant locus | no MR -> candidate analysis |
| atrophic macular degeneration | 0.3 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Vitronectin) |
| gnomAD constraint | pLI=6.4e-13, LOEUF=1.03 — LoF-tolerant |
| GWAS Catalog | 76 unique SNPs / 152 rows |
| ClinVar | 120 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 722 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘VTN’ and resolved to ‘Vitronectin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 120 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 1478 traits by best p-value, aggregated from 2142 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P04004 — UniProt release 2026_02 (10-June-2026)phenome: https://platform.opentargets.org/target/ENSG00000109072/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1075314/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/VTN — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VTN — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VTN%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/VTN — GWAS Catalog search API (live; release not exposed)