MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Chronic kidney disease | 0.194 | 0.0647 | 0.0027 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) | 0.159 | 0.0607 | 0.00877 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | 0.155 | 0.0654 | 0.0175 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: J33 Nasal polyp | 0.257 | 0.114 | 0.0243 | Wald ratio | 1 | cis | NA |
| Primary sclerosing cholangitis | -0.307 | 0.141 | 0.0297 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.144 | 0.0661 | 0.0297 | Wald ratio | 1 | cis | NA |
| Urate | 0.05 | 0.0232 | 0.0314 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse | 0.221 | 0.11 | 0.0452 | Wald ratio | 1 | cis | NA |
| Invasive mucinous ovarian cancer | 0.374 | 0.187 | 0.0455 | Wald ratio | 1 | cis | NA |
| Clear cell ovarian cancer | 0.36 | 0.189 | 0.0564 | Wald ratio | 1 | cis | NA |
| Ovarian cancer | 0.114 | 0.0606 | 0.059 | Wald ratio | 1 | cis | NA |
| Pallidum volume | -15.1 | 8.02 | 0.0602 | Wald ratio | 1 | cis | NA |
| …and 101 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
120 association rows across 57 traits (91 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| EPHB6/VWC2 protein level ratio | 2e-1410 | rs482968 | 1 | GCST90314683 | no MR -> candidate analysis |
| EFNA4/VWC2 protein level ratio | 3e-1371 | rs482968 | 1 | GCST90314607 | no MR -> candidate analysis |
| Circulating VWC2 levels | 2e-1294 | rs482968 | 6 | GCST90859657 | no MR -> candidate analysis |
| LAYN/VWC2 protein level ratio | 5e-1221 | rs482968 | 1 | GCST90315293 | no MR -> candidate analysis |
| VWC2 protein levels | 1e-228 | rs201115864 | 20 | GCST90471064 | no MR -> candidate analysis |
| Brorin levels | 2e-94 | rs1974955 | 5 | GCST90246743 | no MR -> candidate analysis |
| Brorin levels (VWC2.11121.56.3) | 7e-55 | rs372065719 | 4 | GCST90240475 | no MR -> candidate analysis |
| Serum levels of protein VWC2 | 6e-36 | rs79259707 | 2 | GCST90086551 | no MR -> candidate analysis |
| Blood protein levels | 1e-22 | rs79259707 | 1 | GCST006585 | no MR -> candidate analysis |
| Educational attainment | 5e-22 | rs55633081 | 2 | GCST90105038 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 1e-19 | rs10279413 | 3 | GCST90838669 | no MR -> candidate analysis |
| Monocyte percentage (UKB data field 30190) | 4e-19 | rs10269283 | 2 | GCST90468091 | no MR -> candidate analysis |
| …and 45 more traits (see JSON) |
Top diseases by Open Targets association (of 54 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| obesity disorder | 0.658 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.566 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.505 | — | common-variant locus | no MR -> candidate analysis |
| ankylosing spondylitis | 0.482 | — | common-variant locus | MR: beta=-0.249, p=0.345 (cis) |
| Alzheimer disease | 0.478 | — | common-variant locus | no MR -> candidate analysis |
| Pancreatic pseudocyst | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| frozen shoulder | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| psoriatic arthritis | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| keratoconus | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| benign neoplasm of adrenal gland | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| skin disorder | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| nutritional deficiency disease | 0.346 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.048, LOEUF=0.735 — LoF-tolerant |
| GWAS Catalog | 90 unique SNPs / 167 rows |
| ClinVar | 79 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 54 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘VWC2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 79 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 57 traits by best p-value, aggregated from 120 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q2TAL6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000188730/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/VWC2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/VWC2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=VWC2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/VWC2 — GWAS Catalog search API (live; release not exposed)