MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Age at menarche | -0.114 | 0.0267 | 2.10e-05 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | -0.064 | 0.0194 | 9.79e-04 | Wald ratio | 1 | cis | NA |
| Total cholesterol | 0.0788 | 0.0239 | 9.84e-04 | Wald ratio | 1 | cis | NA |
| LDL cholesterol | 0.0776 | 0.0247 | 0.00167 | Wald ratio | 1 | cis | NA |
| Celiac disease | 0.276 | 0.0879 | 0.00171 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.201 | 0.0668 | 0.00261 | Wald ratio | 1 | cis | NA |
| Fasting glucose | 0.0431 | 0.0145 | 0.00295 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | 0.287 | 0.0995 | 0.00387 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | 0.197 | 0.0708 | 0.00544 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.028 | 0.0109 | 0.0105 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] | 0.187 | 0.0743 | 0.012 | Wald ratio | 1 | cis | NA |
| Transferrin | -0.115 | 0.0482 | 0.0176 | Wald ratio | 1 | cis | NA |
| …and 114 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 608 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities | 0.693 | — | established (curated) | no MR -> candidate analysis |
| complex neurodevelopmental disorder | 0.608 | — | established (curated) | no MR -> candidate analysis |
| autosomal recessive primary microcephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| neuronopathy, distal hereditary motor, type 9 | 0.538 | — | established (curated) | no MR -> candidate analysis |
| diabetes mellitus | 0.469 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.403 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.337 | — | common-variant locus | no MR -> candidate analysis |
| hereditary disease | 0.317 | — | established (curated) | no MR -> candidate analysis |
| vertebral disorder | 0.279 | — | common-variant locus | no MR -> candidate analysis |
| schizophrenia | 0.182 | — | established (curated) | MR: beta=-0.0447, p=0.346 (cis) |
| asthma | 0.152 | 0.152 | exploratory rare-variant signal | MR: beta=0.0254, p=0.385 (cis) |
Of the 11 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 1 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Tryptophan–tRNA ligase, cytoplasmic) |
| gnomAD constraint | not available |
| GWAS Catalog | no mapped SNPs |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 608 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘WARS’ and resolved to ‘Tryptophan–tRNA ligase, cytoplasmic’ — confirm this is the intended target.gnomad — No gnomAD constraint data.gwas — No GWAS Catalog SNPs mapped to this gene.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/P23381 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000140105/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6066299/ — ChEMBL_37 (released 2026-05-01)