Protein Dossier — WFIKKN1 (WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.142 |
0.0566 |
0.012 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K20 Oesophagitis |
0.274 |
0.114 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
0.22 |
0.0985 |
0.0254 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries |
0.292 |
0.131 |
0.026 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.0399 |
0.0182 |
0.0286 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis |
0.169 |
0.0802 |
0.0355 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
-0.298 |
0.143 |
0.0368 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.0916 |
0.0448 |
0.0409 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0257 |
0.0126 |
0.0413 |
Wald ratio |
1 |
cis |
NA |
| Urinary albumin-to-creatinine ratio |
0.0739 |
0.0365 |
0.0427 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
0.0394 |
0.0197 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.217 |
0.113 |
0.0543 |
Wald ratio |
1 |
cis |
NA |
| …and 91 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3191_50_2 |
WFKN1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
12 association rows across 9 traits (10 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating WFIKKN1 levels |
1e-271 |
rs17139376 |
3 |
GCST90859694 |
no MR -> candidate analysis |
| Height |
1e-253 |
rs4984903 |
2 |
GCST90245848 |
MR: beta=0.0399, p=0.0286 (cis) |
| MSLN protein levels |
2e-40 |
rs374542712 |
1 |
GCST90469948 |
no MR -> candidate analysis |
| Body size or adipose distribution (multivariate analysis) |
7e-25 |
rs4984903 |
1 |
GCST90624105 |
no MR -> candidate analysis |
| Mean corpuscular haemoglobin concentration (UKB data field 3 |
1e-24 |
rs35800913 |
1 |
GCST90468085 |
no MR -> candidate analysis |
| HBQ1 protein levels |
6e-13 |
rs9929621 |
1 |
GCST90469434 |
no MR -> candidate analysis |
| Height (standard GWA) |
2e-10 |
rs10153076 |
1 |
GCST90267284 |
no MR -> candidate analysis |
| Cystatin C levels in bottom 99% of individuals by creatinine |
3e-8 |
rs34080030 |
1 |
GCST90566734 |
no MR -> candidate analysis |
| Height (weighted GWA) |
2e-7 |
rs10153076 |
1 |
GCST90267285 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0021, LOEUF=2.59 — LoF-tolerant |
| GWAS Catalog |
122 unique SNPs / 302 rows |
| ClinVar |
219 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 664 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘WFIKKN1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 219 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 9 of 9 traits by best p-value, aggregated from 12 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q96NZ8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000127578/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/WFIKKN1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/WFIKKN1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=WFIKKN1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/WFIKKN1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:37:50 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none