Protein Dossier — WFIKKN2 (WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
-0.0177 |
0.00347 |
3.61e-07 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.0156 |
0.00393 |
7.39e-05 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0126 |
0.00402 |
0.00178 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: B37 Candidiasis |
0.374 |
0.131 |
0.00442 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
-0.0122 |
0.00459 |
0.00766 |
Wald ratio |
1 |
cis |
NA |
| HOMA-IR |
-0.0168 |
0.00643 |
0.00882 |
Wald ratio |
1 |
cis |
NA |
| Ischemic stroke |
0.0722 |
0.0279 |
0.0095 |
Wald ratio |
1 |
cis |
NA |
| Neuroticism |
0.0153 |
0.00612 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
-9.67 |
3.89 |
0.013 |
Wald ratio |
1 |
cis |
NA |
| Type 2 diabetes |
-0.0452 |
0.0191 |
0.0176 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
-0.122 |
0.0517 |
0.0182 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone |
0.0951 |
0.0404 |
0.0186 |
Wald ratio |
1 |
cis |
NA |
| …and 107 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3235_50_2 |
WFKN2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
57 association rows across 30 traits (50 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating WFIKKN2 levels |
1e-2338 |
rs10853117 |
7 |
GCST90860623 |
no MR -> candidate analysis |
| WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing |
4e-342 |
rs7225019 |
1 |
GCST90425667 |
no MR -> candidate analysis |
| WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing |
2e-341 |
rs11079936 |
7 |
GCST90250211 |
no MR -> candidate analysis |
| WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing |
3e-324 |
rs7225019 |
1 |
GCST90422127 |
no MR -> candidate analysis |
| Serum levels of protein WFIKKN2 |
4e-175 |
rs11079936 |
2 |
GCST90087425 |
no MR -> candidate analysis |
| WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing |
9e-166 |
rs7225465 |
2 |
GCST90243358 |
no MR -> candidate analysis |
| Blood protein levels |
2e-94 |
rs12946082 |
3 |
GCST006585 |
no MR -> candidate analysis |
| WFIKKN2 protein levels |
5e-87 |
rs80125006 |
11 |
GCST90471077 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein WFIKKN2 levels |
1e-44 |
rs4533326 |
1 |
GCST90944661 |
no MR -> candidate analysis |
| Growth/differentiation factor 11/8 levels |
1e-40 |
rs11079936 |
1 |
GCST90247707 |
no MR -> candidate analysis |
| Growth/differentiation factor 8 (analyte X12077.32) levels |
1e-37 |
rs4611502 |
1 |
GCST90421646 |
no MR -> candidate analysis |
| Height |
8e-35 |
rs4794187 |
1 |
GCST90245848 |
MR: beta=-0.00918, p=0.0608 (cis) |
| …and 18 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 234 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| osteoarthritis, hip |
0.651 |
— |
common-variant locus |
MR: beta=0.0309, p=0.332 (cis) |
| total joint arthroplasty |
0.479 |
— |
common-variant locus |
no MR -> candidate analysis |
| total hip arthroplasty |
0.479 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis, knee |
0.479 |
— |
common-variant locus |
MR: beta=0.0309, p=0.332 (cis) |
| bone remodeling disease |
0.342 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 5 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=7.5e-06, LOEUF=0.892 — LoF-tolerant |
| GWAS Catalog |
73 unique SNPs / 146 rows |
| ClinVar |
127 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 234 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘WFIKKN2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 127 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 57 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q8TEU8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000173714/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/WFIKKN2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/WFIKKN2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=WFIKKN2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/WFIKKN2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:38:02 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none