MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: bone disorder | 0.534 | 0.167 | 0.00136 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema | -0.191 | 0.0697 | 0.00602 | Wald ratio | 1 | cis | NA |
| Birth weight | -0.0508 | 0.0202 | 0.0117 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.255 | 0.113 | 0.0236 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: H25 Senile cataract | 0.252 | 0.116 | 0.0298 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.0199 | 0.0101 | 0.0475 | Wald ratio | 1 | cis | NA |
| Low grade serous ovarian cancer | 0.56 | 0.285 | 0.0495 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | -0.0434 | 0.0229 | 0.0583 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.181 | 0.0958 | 0.0585 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R35 Polyuria | 0.282 | 0.16 | 0.0785 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | 0.152 | 0.0896 | 0.0893 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | 0.0847 | 0.0524 | 0.106 | Wald ratio | 1 | cis | NA |
| …and 57 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
177 association rows across 99 traits (93 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-300 | rs75884405 | 5 | GCST90321120 | no MR -> candidate analysis |
| Height | 3e-42 | rs4320032 | 10 | GCST90245848 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 3e-28 | rs823037 | 3 | GCST90838669 | no MR -> candidate analysis |
| Atrial fibrillation | 6e-26 | rs60902112 | 6 | GCST90624411 | MR: beta=-0.113, p=0.418 (cis) |
| Basophil (fraction, mean, inv-norm transformed) | 2e-25 | rs823035 | 2 | GCST90475139 | no MR -> candidate analysis |
| Xyloside xylosyltransferase 1 levels (XXYLT1.6375.75.3) | 4e-25 | rs36082205 | 1 | GCST90243370 | no MR -> candidate analysis |
| Hematocrit | 8e-25 | rs1075871 | 5 | GCST90002383 | no MR -> candidate analysis |
| Red blood cell count | 2e-24 | rs1075871 | 7 | GCST90002403 | no MR -> candidate analysis |
| Hemoglobin | 4e-24 | rs1075871 | 2 | GCST90002384 | no MR -> candidate analysis |
| Hemoglobin concentration | 6e-24 | rs711991 | 4 | GCST90002310 | no MR -> candidate analysis |
| Basophil (fraction, maximum, inv-norm transformed) | 1e-22 | rs2676847 | 2 | GCST90475136 | no MR -> candidate analysis |
| Red blood cell erythrocyte count (UKB data field 30010) | 3e-22 | rs1075871 | 1 | GCST90468098 | no MR -> candidate analysis |
| …and 87 more traits (see JSON) |
Top diseases by Open Targets association (of 113 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| atrial fibrillation | 0.818 | — | common-variant locus | MR: beta=-0.113, p=0.418 (cis) |
| venous thromboembolism | 0.509 | 0.152 | multi-layer: burden+GWAS (allelic-series candidate) | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.622 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.546 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.506 | — | common-variant locus | no MR -> candidate analysis |
| major salivary gland cancer | 0.487 | — | common-variant locus | no MR -> candidate analysis |
| exostosis | 0.486 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| placental retention | 0.483 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.451 | — | common-variant locus | no MR -> candidate analysis |
| kidney disorder | 0.429 | — | common-variant locus | no MR -> candidate analysis |
| respiratory tract infectious disorder | 0.24 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the breast | 0.231 | — | common-variant locus | no MR -> candidate analysis |
| deep vein thrombosis | 0.163 | 0.163 | exploratory rare-variant signal | no MR -> candidate analysis |
| Retinal dystrophy | 0.152 | 0.152 | exploratory rare-variant signal | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 2 exploratory rare-variant signal(s), 1 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2e-05, LOEUF=1 — LoF-tolerant |
| GWAS Catalog | 100 unique SNPs / 179 rows |
| ClinVar | 146 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 113 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘XXYLT1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 146 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 99 traits by best p-value, aggregated from 177 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8NBI6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000173950/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/XXYLT1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/XXYLT1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=XXYLT1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/XXYLT1 — GWAS Catalog search API (live; release not exposed)